Research

Groundbreaking work and published results in peer reviewed journals across disciplines.

Title

Topic

  • ‘The Clinical Trials Puzzle: How Network Effects Limit Drug Discovery’

    “The depth of knowledge offered by post-genomic medicine has carried the promise of new drugs, and cures for multiple diseases. To explore the degree to which this capability has materialized, we extract meta-data from 356,403 clinical trials spanning four decades, aiming to offer mechanistic insights into the innovation practices in drug discovery. We find … the tested drugs target only 12% of the human interactome. If current patterns persist, it would take 170 years to target all druggable proteins.” Read the paper and see the full list of authors in ArXiv.

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  • ‘HoLA Robots: Mitigating Plan-Deviation Attacks in Multi-Robot Systems’

    “Emerging multi-robot systems rely on cooperation between humans and robots, with robots following automatically generated motion plans to service application-level tasks. Given the safety requirements associated with operating in proximity to humans and expensive infrastructure, it is important to understand and mitigate the security vulnerabilities of such systems. … We focus on centralized systems, where a *central entity* (CE) is responsible for determining and transmitting the motion plans to the robots, which report their location as they move following the plan.” Read the paper and see the full list of authors in ArXiv.

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  • Paper from the Ocean Genome Legacy Center, ‘Greater Than pH 8: The pH Dependence of EDTA as a Preservative of High Molecular Weight DNA’

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    “Ethylenediaminetetraacetic acid (EDTA) is a divalent cation chelator and chemical preservative that has been shown to be the active ingredient of the popular DNA preservative DESS. EDTA may act to reduce DNA degradation during tissue storage by sequestering divalent cations that are required by nucleases naturally occurring in animal tissues. … Increasing the pH of EDTA-containing preservative solutions may improve their effectiveness as DNA preservatives.” Read “Greater Than pH 8: The pH Dependence of EDTA as a Preservative of High Molecular Weight DNA in Biological Samples” and find the full list of authors in PLOS ONE.

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  • ‘Single-Pass Streaming Algorithms for Correlation Clustering’

    “We study correlation clustering in the streaming setting. This problem has been studied extensively and numerous algorithms have been developed, most requiring multiple passes over the stream. … We present a single-pass algorithm that obtains a 5-approximation using O(n) space. The algorithm itself is extremely simple and has implications beyond the streaming setting (such as for dynamic and local computation algorithms). The approximation analysis, on the other hand, is delicate and in fact tight.” Read the paper and see the full list of authors in the Society for Industrial and Applied Mathematics.

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  • ‘Dynamic Algorithms for Maximum Matching Size’

    “We study fully dynamic algorithms for maximum matching. This is a well-studied problem, known to admit several update-time/approximation trade-offs. For instance, it is known how to maintain a 1/2-approximate matching in (poly log n) update time or a 2/3-approximate match­ing in O(√n) update time, where n is the number of vertices. … We show that when the goal is to maintain just the size of the matching (and not its edge-set), then these bounds can indeed be improved.” Read the paper and see the full list of authors in the Society for Industrial and Applied Mathematics.

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  • ‘Decadal Application of WRF/Chem Under Future Climate and Emission Scenarios’

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    “This work presents new climate and emissions scenarios to investigate changes on future meteorology and air quality in the U.S. Here, we employ a dynamically downscaled Weather Research and Forecasting model coupled with chemistry (WRF/Chem) simulations that use two Intergovernmental Panel on Climate Change scenarios (i.e., A1B and B2) integrated with explicitly projected emissions from a novel Technology Driver Model (TDM).” Read “Decadal Application of WRF/Chem Under Future Climate and Emission Scenarios: Impacts of Technology-Driven Climate and Emission Changes on Regional Meteorology and Air Quality” and see the full list of authors in Atmosphere.

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  • ‘Who Wants To Cooperate—And Why? Attitude and Perception of Crowd Workers in Online Labor Markets’

    “Existing literature and studies predominantly focus on how crowdsource workers individually complete tasks and projects. Our study examines crowdsource workers’ willingness to work collaboratively. We report results from a survey of 122 workers on a leading online labor platform (Upwork) to examine crowd workers’ behavioral preferences for collaboration. … We then test if actual cooperative behavior matches with workers’ behavioral preferences through an incentivized social dilemma experiment. We find that respondents cooperate at a higher rate (85%) than reported in previous comparable studies (between 50-75%).” Read the paper and see the full list of authors in ArXiv.

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  • ‘Interphase Chromosomes of the Aedes Aegypti Mosquito Are Liquid Crystalline and Can Sense Mechanical Cues’

    In “Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues,” the authors observe “the three-dimensional architecture of the Aedes aegypti genome,” a species of mosquito. Their observations “[provide] a possible physical mechanism linking mechanical cues to gene regulation.” Find the paper and the full list of authors at Nature Communications.

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  • Building a better hologram: Just add noise

    Researchers from Northeastern University, in collaboration with Nanjing University, have broken a “theoretical limit” in metasurface capacities—a.k.a. “holograms.” By introducing carefully engineered noise into Jones matrices, they have produced “the highest capacity reported for polarization multiplexing.” They demonstrate this raised capacity across “11 independent holographic images.” Read “Breaking the Limitation of Polarization Multiplexing in Optical Metasurfaces with Engineered Noise” and find the full list of authors at Science.

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  • ‘Lineage-Mismatched Mitochondrial Replacement … Effectively Restores the Original Proteomic Landscape of Recipient Cells’

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    “Here an inducible mitochondrial depletion modelis used to study how cells lacking endogenous mitochondria respond, on a global protein expression level, to transplantation with lineage-mismatched (LM) mitochondria. It is shown that LM mitochondrial transplantation does not alter the proteomic profile in nonmitochondria–depleted recipient cells; however, enforced depletion of endogenous mitochondria results in dramatic changes in the proteomic landscape, which returns to the predepletion state following internalization of LM mitochondria.” Find “Lineage-Mismatched Mitochondrial Replacement in an Inducible Mitochondrial Depletion Model Effectively Restores the Original Proteomic Landscape of Recipient Cells” and the full list of authors in Advanced Biology.

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  • The straightest line between two points: When your map’s incomplete

    The authors of “Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping” have determined that large, real-world networks “are not random but are organized according to latent-geometric rules.” This being the case, they argue that, when “mapped to points in latent hyperbolic spaces,” they can calculate shortest paths “along geodesic curves connecting endpoint nodes.” In other words, they can get from A to C, without knowing B’s location. Read “Finding shortest and nearly shortest path nodes in large substantially incomplete networks by hyperbolic mapping” and see the full list of authors in Nature Communications.

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  • How the ‘two ingredients of language’ come from different regions of the brain

    The authors of “Phonetic Categorization Relies on Motor Simulation, But Combinatorial Phonological Computations Are Abstract” note two elements required in human language, categorization (identifying words as “distinct units”) and combination (distinguishing between units). The authors explore these mechanisms “using transcranial magnetic stimulation. [They] show that speech categorization engages the motor system. … In contrast, the combinatorial computation of syllable structure engages Broca’s area,” a region within the brain’s frontal lobe. They “conclude that the two ingredients of language—categorization and combination—are distinct functions in human brains.” Read their paper and see the full list of authors in Scientific Reports.

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  • ‘Byzantine Resilience at Swarm Scale: A Decentralized Blocklist Protocol From Inter-Robot Accusations’

    “The Weighted-Mean Subsequence Reduced (W-MSR) algorithm, the state-of-the-art method for Byzantine-resilient design of decentralized multi-robot systems, is based on discarding outliers received over Linear Consensus Protocol (LCP). Although W-MSR provides well-understood theoretical guarantees relating robust network connectivity to the convergence of the underlying consensus, the method comes with several limitations preventing its use at scale. … In this work, we propose a Decentralized Blocklist Protocol (DBP) based on inter-robot accusations.” Read the paper and see the full list of authors in ArXiv.

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  • ‘Beating (1 – 1/e)-Approximation for Weighted Stochastic Matching’

    “In the stochastic weighted matching problem, the goal is to find a large-weight matching of a graph when we are uncertain about the existence of its edges. In particular, each edge e has a known weight we but is realized independently with some probability pe. The algorithm may query an edge to see whether it is realized. We consider the well-studied query commit version of the problem, in which any queried edge that happens to be realized must be included in the solution.” Find the paper and the full list of authors at SIAM.

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  • ‘Beating Greedy Matching in Sublinear Time’

    “We study sublinear time algorithms for estimating the size of maximum matching in graphs. Our main result is a (½ + Ω(1))-approximation algorithm which can be implemented in O(n1+ε) time, where n is the number of vertices and the constant ε > 0 can be made arbitrarily small. The best known lower bound for the problem is Ω(n), which holds for any constant approximation.” Read the paper and see the full list of authors at the Society for Industrial and Applied Mathematics.

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  • ‘Single-Pass Streaming Algorithms for Correlation Clustering’

    “We study correlation clustering in the streaming setting. This problem has been studied extensively and numerous algorithms have been developed, most requiring multiple passes over the stream. For the important case of single-pass algorithms, recent work of Assadi and Wang [8] obtains a c-approximation using Õ(n) space where c > 105 is a constant and n is the number of vertices to be clustered. We present a single-pass algorithm that obtains a 5-approximation using O(n) space.” Read the paper and see the full list of authors at the Society for Industrial and Applied Mathematics.

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  • ‘Dynamic Algorithms for Maximum Matching Size’

    “We study fully dynamic algorithms for maximum matching. This is a well-studied problem, known to admit several update-time/approximation trade-offs. … It has been a long-standing open problem to determine whether either of these bounds can be improved. In this paper, we show that when the goal is to maintain just the size of the matching (and not its edge-set), then these bounds can indeed be improved.”

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  • ‘Sublinear Algorithms for TSP via Path Covers’

    “We study sublinear time algorithms for the traveling salesman problem (TSP). First, we focus on the closely related maximum path cover problem, which asks for a collection of vertex disjoint paths that include the maximum number of edges. Our analysis of the running time uses connections to parallel algorithms and is information-theoretically optimal up to poly log n factors. Additionally, we show that our approximation guarantees for path cover and (1,2)-TSP hit a natural barrier: We show better approximations require better sublinear time algorithms for the well-studied maximum matching problem.” Find the paper and full list of authors at ArXiv.

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  • Chowdhury awarded patent for intelligent wi-fi access points

    Professor Kaushik Chowdhury received a patent for work on the “Method and apparatus for access point discovery in dense WiFi networks.” The abstract to the patent offers “Systems, devices, and methods for access point discovery in a wireless network,” which rely on phase shift methods “encoded into bits in selected ones of a plurality of subcarriers.”

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  • Rethinking the source: COVID-19 and global supply chains in 2023

    In the wake of the COVID-19 pandemic, distinguished professor Nada Sanders tracks “three major shifts in how companies manage their supply chains.” According to her analysis, both customers and businesses will be impacted by the force of: 1) Bringing supply chains home, 2) investments in more technology, and 3) a shift from “just-in-time” thinking to “just-in-case” processes. The goal through all of these changes, Sanders writes, “is to ensure [that companies] can withstand disruptions and maintain business continuity.” To read more about these three forces and their potential impacts on the economy, see her article in The Conversation.

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  • Online ‘oracle reviewers’ serve as bellwethers of success

    Professor of marketing in the D’Amore-McKim School of Business Yael Karlinsky Shichor, with co-author Verena Schoenmueller of the ESADE Business School, have identified “oracle reviewers” in online product reviews, “whose early reviews serve as a signal to various measures of future book success.” The researchers used “unique data of Amazon book reviews” to generate a “reviewer score” that identifies how often a particular reviewer reviewed “successful books early on.” The more of these highly successful “oracle reviewers” appeared in a population of reviews, the more likely a book was to succeed. Read “The Oracles of Online Reviews” in SSRN.

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  • Machine learning at play while ‘Rethinking Bacterial Relationships in Light of Their Molecular Abilities’

    “Determining the repertoire of a microbe’s molecular functions is a central question in microbial genomics. Modern techniques achieve this goal by comparing microbial genetic material against reference databases of functionally annotated genes/proteins or known taxonomic markers such as 16S rRNA. Here we describe a novel approach to exploring bacterial functional repertoires without reference databases.” See the paper and the full list of authors at BioRxiv.

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  • The actual motivations behind Walmart’s controversial Women’s Empowerment Program

    Eileen Otis, professor of sociology in the College of Social Sciences and Humanities, has a new article in Gender & Society teasing apart the “Walmart’s Women’s Empowerment Program,” which some media outlets treated as a cause célèbre. Otis, however, notes that “a closer look at the program reveals a set of actions that are at best insignificant to women working for Walmart, at worst detrimental to women’s status in the workplace.” Read “Walmart… empowering women?” at Gender & Society.

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  • ‘Philosophy of Perception in the Psychologist’s Laboratory’

    “Unlike more general sources of philosophical inspiration, the work described here draws a direct line from a prominent philosophical conjecture or thought experiment about perception to a key test of that question in the laboratory—such that the relevant experimental work would not (and even could not) have proceeded as it did without the preceding philosophical discussion.” Find the paper and the full list of authors at the Association for Psychological Science.

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  • Protein identification methods: Now digestion free

    Whereas sequencing proteins generally involves “digestion into short peptides before detection and identification,” the authors of this paper have “developed a digestion-free method to chemically unfold and ‘scan’ full-length proteins through a nanopore,” they wrote in a summary of this paper. Read “Unidirectional single-file transport of full-length proteins through a nanopore” and see the full list of authors Nature Biotechnology.

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  • Special issue of Ethnic and Racial Studies on ‘cultural taxation’ receives introduction co-authored by Northeastern professor

    Tiffany Joseph, professor of sociology and international affairs, writing with Laura Hirshfield of the University of Illinois College of Medicine, have written the introduction to a special issue of Ethnic and Racial Studies. This issue focuses on the concept of “cultural taxation,” the “extra burdens that stem from faculty of colour’s commitment to campus diversity issues and the lack of legitimacy they experience from colleagues challenging their existence in the academy,” they write.

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  • Untangling single-cell proteins with the Slavov Laboratory

    “Inside Precision Medicine published an article entitled ‘Untangling the Complexities of Single Cell Protein Analysis’ that highlights the latest research from the team of Allen Distinguished Investigator and associate professor of bioengineering Nikolai Slavov.  Read the article and more about the research team at Inside Precision Medicine.

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  • ‘Characterization of Bispecific Antigen-Binding Biotherapeutic Fragmentation Sites’

    “Characterization of the fragmentation pattern of a therapeutic protein is traditionally accomplished using capillary gel electrophoresis with UV detection under both non-reducing and reducing conditions. … Here, we present a novel method to characterize size-based fragmentation variants of a new biotherapeutic kind using microfluidic ZipChip® capillary zone electrophoresis (mCZE) system interfaced with mass spectrometry (MS) to determine the molecular masses of fragments.” Read the paper and see the full list of authors in Analyst.

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  • ‘DCVNet: Dilated Cost Volume Networks for Fast Optical Flow’

    “The cost volume, capturing the similarity of possible correspondences across two input images, is a key ingredient in state-of-the-art optical flow approaches. When sampling correspondences to build the cost volume, a large neighborhood radius is required to deal with large displacements, introducing a significant computational burden. To address this, coarse-to-fine or recurrent processing of the cost volume is usually adopted. … In this paper, we propose an alternative by constructing cost volumes with different dilation factors to capture small and large displacements simultaneously.” Read the paper and see the full list of authors in IEEE Xplore.

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  • Facial recognition by any memes necessary

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    “As part of ‘JUSTICE,’ an exhibit opening at the Science Gallery Atlanta at Emory University in January 2023,” writes the College of Arts, Media and Design, “professors Derek Curry and Jennifer Gradecki have created the faux surveillance company Boogaloo Bias, a facial recognition tool aimed at finding suspected members of the Boogaloo Bois, an anti-law enforcement militia that emerged from 4chan meme culture and has been present at protests since January 2020. … This interactive artwork and research project highlights some of the known problems with law enforcement agencies’ use of facial recognition technologies.”

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