Title
Topic
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‘Simplified Internal Models in Human Control of Complex Objects’
“Humans are skillful at manipulating objects that possess nonlinear underactuated dynamics, such as clothes or containers filled with liquids. Several studies suggested that humans implement a predictive model-based strategy to control such objects. However, these studies only considered unconstrained reaching without any object involved or. … This study examined a task where participants physically interacted with a nonlinear underactuated system mimicking a cup of sloshing coffee: a cup with a ball rolling inside. … These findings provide evidence that humans use simplified internal models along with mechanical impedance to manipulate complex objects.”Find the paper and list of authors in PLOS Computational…
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‘Is Technology Uniquely Placed to Solve Our Problems? An Examination Into Technosolutionism, What It Entails and What It Predicts’
“Technology plays an important role in business and society. This has resulted in the belief that technology is in a unique position to solve organizational and societal problems. However, technology is not regarded as equally impactful by all. To explore these differences, we designed a technosolutionism scale to measure the extent to which individuals deem technological solutions to be better-suited to address organizational and societal problems.” Find the paper and full list of authors in Sage Business & Society.
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‘Axolotl Retina Regeneration Following NMDA Injury’
“While axolotls (Ambystoma mexicanum) are studied for their remarkable ability to regenerate, there is a lack in understanding on their ability to regenerate their retina and the source of the progenitors responsible. It is also not known if the regeneration process is damage specific and if all retinal cell classes and types can regenerate. … This study serves to investigate the regenerative potential of the axolotl retina following chemical injury. We … discovered that axolotls contain all the major cell types of the vertebrate retina.”Find the paper and full list of authors in Investigative Ophthalmology and Visual Science.
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‘The Corporate Governance of Business Groups Around the World: A Review and Agenda for Future Research’
“Scholarly interest in business groups (BGs) has grown considerably over the years, as they emerged as important players in the global economy. Yet, there exist ample differences in the corporate governance, strategies, and performance of BG-affiliated firms. … Our review of 301 articles published in highly ranked journals between 1986 and 2023 establishes a mechanism-based framework to explain the effect of BG affiliation, ownership structure and corporate governance practices on firm performance. We also reveal that many relationships between these factors vary cross-nationally and over time.”Find the paper and full list of authors in Corporate Governance.
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‘Effective Nose-to-Brain Delivery of Blood-Brain Barrier Impermeant Anti-IL-1β Antibody via… MIND Technique’
“Treatment of neuroinflammation and neurodegenerative diseases using biologic therapies is limited due to the blood-brain barrier (BBB). This study explores a clinically validated approach to bypass the BBB for the purposes of direct central nervous system (CNS) delivery of antibodies using the Minimally Invasive Nasal Depot (MIND) technique. … The results demonstrated that MIND delivery resulted in a significant reduction in IL-1β levels and microglial activation in relevant brain regions, notably outperforming conventional intravenous (IV) administration.” Find the paper and full list of authors in ACS Applied Materials & Interfaces.
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‘Murine model of minimally invasive nasal depot (MIND) technique for central nervous system delivery of … therapeutics’
“The blood–brain barrier (BBB) poses a substantial obstacle to the successful delivery of therapeutics to the central nervous system (CNS). The transnasal route has been extensively explored, but success rates have been modest. … Here, to address these issues, we have developed a surgical technique known as the minimally invasive nasal depot (MIND). … The MIND procedure represents a unique platform that can be used to overcome the limitations posed by the BBB. This technique can potentially expand the therapeutic toolkit in the treatment of neurological diseases.” Find the paper and full list of authors in Lab Animal.
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‘Advancing Delirium Treatment Trials in Older Adults: Recommendations for Future Trials’
“To provide background and context, a review of delirium treatment randomized controlled trials (RCTs) published between 2003 and 2023 was conducted and evidence gaps were identified. The four panels addressed the identified subtopics. For each subtopic, research challenges were identified and recommendations to address each were proposed. … We identified key evidence gaps through a systematic literature review, yielding 43 RCTs of delirium treatments. From this review, eight unique challenges for delirium treatment trials were identified, and recommendations to address each were made based on panel input.”Find the paper and full list of authors in Critical Care Medicine.
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‘Weak Lensing Mass Distributions, Red-sequence Galaxy Distributions, and Their Alignment with the Brightest Cluster Galaxy’
“The Local Volume Complete Cluster Survey is an ongoing program to observe nearly a hundred low-redshift X-ray-luminous galaxy clusters … with the Dark Energy Camera, capturing data in [multiple] bands with a 5σ point source depth of approximately 25th–26th AB magnitudes. Here, we map the aperture masses in 58 galaxy cluster fields using weak gravitational lensing. … We find that the orientations of the BCG and the RS distribution are strongly aligned throughout the [cluster] interiors. … These types of alignment suggest long-term dynamical evolution within the clusters over cosmic timescales.” Find the paper and full list of authors in The…
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‘Interplay of Nano-Based Delivery Systems and Protein Signalling in Ameliorating Lung Diseases’
“This review explores the intricate interplay between the nano-based drug delivery and protein signalling pathways involved in the pathogenesis and management of lung diseases. The key advancements and challenges in the field are discussed, highlighting the potential of nanomedicine to redefine the landscape for the management of lung diseases. This will ultimately provide new opportunities for pulmonary clinics and reduce the massive burden that is faced across the globe due to various lung diseases.” Find the paper and full list of authors in Journal of Drug Delivery Science and Technology.
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Patent for ‘Compounds for Treating Cannabinoid Toxicity’
“The present invention relates to novel compounds that can act as antidotes for treating “Acute Cannabinoid Overdose” produced by classical cannabinoids such as Δ9-tetrahydrocannabinol (THC) and several synthetic psychoactive cannabinoids (SPCs).” Find the paper and full list of authors at the link.
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‘Enhanced Cytotoxicity of 5-Fluorouracil Against Skin Cancer Cell Lines and 3D Spheroid Tumor Model Using Solid Lipid Nanoparticles’
“This study aimed to develop solid lipid nanoparticles containing 5-fluorouracil (5-FU loaded PGSLNs) to achieve desired physicochemical properties and to enhance in vitro cytotoxicity against monolayered and 3D spheroid skin tumor models. 5-FU loaded PGSLNs were prepared via cold homogenization using Glyceryl Palmitostearate (GP) and Geleol® as solid lipids and Poloxamer 188 and Tween 80 as surfactant and co-surfactant, respectively. … The designed solid lipid nanoparticles significantly enhanced the cytotoxic effect of 5-FU against monolayered and 3D spheroid skin tumor models and can be used as promising approach for skin cancer.” Find the paper and full list of authors in…
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‘Microfluidic-Chip-Based Formulation and In Vivo Evaluations of Squalene Oil Emulsion Adjuvants for Subunit Vaccines’
“Adjuvants play a crucial role in improving the immunogenicity of various antigens in vaccines. Squalene-in-water emulsions are clinically established vaccine adjuvants that improve immune responses, particularly during a pandemic. … In this study, we explored the feasibility of a microfluidic chip platform to address these challenges and evaluated the adjuvanticity of the emulsion adjuvant prepared using the microfluidic chip process in CB6F1 mice model, and compared it with a control formulation. … These findings demonstrate a proof of concept for using microfluidic chip platforms for formulating emulsion adjuvants.”Find the paper and full list of authors in Vaccines.
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‘Expanding Use of Continuous Glucose Monitoring in Type 2 Diabetes’
“A comprehensive literature search from 2008 to 2024 was conducted using PubMed, using key terms including “type 2 diabetes,” “continuous glucose monitoring,” and “non-insulin.” The search included high-impact and peer-reviewed journals dedicated to diabetes research and technology, such as Diabetes Technology & Therapeutics and Diabetes Spectrum. … Based on their relevance to the topic, 4 randomized controlled trials and 2 retrospective/observational studies were selected. … The findings from each study were then analyzed to provide insights into the effectiveness of CGMs in non-insulin-treated T2DM.” Find the paper and full list of authors in ADCES.
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‘Disulfiram-Containing Polymeric Nanocapsules With Anticancer Activity for Cancer Treatment’
“Disulfiram, a medication traditionally used to treat alcohol addiction, has gained attention as a potential cancer treatment in recent years. Disulfiram works by inhibiting the enzyme aldehyde dehydrogenase, involved in the breakdown of acetaldehyde, a by-product of alcohol metabolism. This results in the build up of acetaldehyde in the body leading to unpleasant side effects such as nausea and vomiting when alcohol is consumed while taking the drug. With cancer treatment, disulfiram has been found to have several mechanisms of action.”Find the paper and full list of authors in the International Journal of Pharmaceutics.
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‘Detection of ChatGPT Fake Science With the xFakeSci Learning Algorithm’
“Generative AI tools exemplified by ChatGPT are becoming a new reality. This study is motivated by the premise that “AI generated content may exhibit a distinctive behavior that can be separated from scientific articles”. In this study, we show how articles can be generated using means of prompt engineering for various diseases and conditions. We then show how we tested this premise in two phases and prove its validity.” Find the paper and full list of authors in Nature Scientific Reports.
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‘Nonlinear Optical Responses in Multiorbital Topological Superconductors’
“We theoretically study first- and second-order optical responses in a transition-metal dichalcogenide monolayer with distinct trivial, nodal, and time-reversal invariant topological superconducting (TRITOPS) phases. We show that the second-order dc response, also known as the photogalvanic response, contains signatures for differentiating these phases while the first-order optical response does not. We find that the high-frequency photogalvanic response is insensitive to the phase of the system, while the low-frequency response exhibits features distinguishing the three phases.” Find the paper and full list of authors in Physical Review B.
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‘A Computational Account of Transsaccadic Attentional Allocation Based on Visual Gain Fields’
“Saccadic eye movements are the primary means by which people gather information about the environment. An average fixation duration is a fraction of a second in natural viewing conditions. … How the brain maintains perceptual stability across these interruptions remains a mystery. Here, we combined a unique psychophysical protocol with bespoke analytical tools to investigate such active vision with greater spatial and temporal resolution than ever before. We show that the visual system can compute a visual object’s real-world position in the earliest stages of processing, thereby allowing precise object tracking across saccades.” Find the paper and authors list in…
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‘Improved Data Acquisition Settings on … Mass Spectrometers for Proteomic Analysis of Limited Samples’
“Deep proteomic profiling of complex biological and medical samples available at low nanogram and subnanogram levels is still challenging. Thorough optimization of settings, parameters, and conditions in nanoflow liquid chromatography-tandem mass spectrometry (MS)-based proteomic profiling is crucial for generating informative data using amount-limited samples. This study demonstrates that by adjusting selected instrument parameters, … and minimally altering the conditions for resuspending or storing the sample in solvents of different compositions, up to 15-fold more thorough proteomic profiling can be achieved compared to conventionally used settings.” Find the paper and full list of authors in the Journal of Proteome Research.
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‘Machine Learning for Prediction of Protein Function and Elucidation of Enzyme Function and Control’
“Our machine learning methodology, partial order optimum likelihood (POOL) is used to predict biochemically active amino acids in the three-dimensional structures of proteins. Computed electrostatic and chemical properties of individual amino acids serve as input features. Our most recent applications of POOL are described. From predicted local sites of biochemical activity, the biochemical functions of structural genomics proteins of unknown function are predicted by local structure matching of predicted spatial arrays of active amino acids with those of proteins of known function.” Find the paper and full list of authors in Biophysical Journal.
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‘Giant Effective Magnetic Moments of Chiral Phonons From Orbit-Lattice Coupling’
“Circularly polarized lattice vibrations carry angular momentum and lead to magnetic responses in applied magnetic fields or when resonantly driven with ultrashort laser pulses. Recent measurements have found responses that are orders of magnitude larger than those calculated in prior theoretical studies. Here, we present a microscopic model for the effective magnetic moments of chiral phonons in magnetic materials that can reproduce the experimentally measured magnitudes and that allows us to make quantitative predictions for materials with giant magnetic responses using microscopic parameters.” Find the paper and full list of authors in Physical Review B.
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‘From Universal Owners to Owners of the Universe? How the Big Three are Reshaping Corporate Governance’
“The prominent ownership position of the Big Three asset management firms (i.e., BlackRock, Vanguard, and State Street Global Advisors) in many leading companies around the world has sparked a lively debate regarding whether their concentration of power is beneficial or detrimental for corporate governance (CG). We conduct a comprehensive literature review of extant empirical research examining the link between the Big Three and CG dimensions.” Find the paper and full list of authors in S&P Global Market Intelligence.
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‘Intrinsic symmetry-protected topological mixed state from modulated symmetries and hierarchical structure of boundary anomaly’
“We introduce a class of intrinsic symmetry-protected topological mixed state (mSPT) in open quantum systems that feature modulated symmetries, such as dipole and subsystem symmetries. Intriguingly, these mSPT phases cannot be realized as the ground states of a gapped Hamiltonian under thermal equilibrium. The microscopic form of the density matrix characterizing these intrinsic mixed-state SPT ensembles is constructed using solvable coupled-wire models that incorporate quenched disorder or quantum channels. A detailed comparison of the hierarchical structure of boundary anomalies in both pure and mixed states is presented.” Find the paper and full list of authors in Physical Review B.
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‘Effective Theory Building and Manifold Learning’
“Manifold learning and effective model building are generally viewed as fundamentally different types of procedure. After all, in one we build a simplified model of the data, in the other, we construct a simplified model of the another model. Nonetheless, I argue that certain kinds of high-dimensional effective model building, and effective field theory construction in quantum field theory, can be viewed as special cases of manifold learning. I argue that this helps to shed light on all of these techniques.”