Title
Topic
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‘Red Light-Activated Depletion of Drug-Refractory Glioblastoma Stem Cells and Chemosensitization of an Acquired-Resistant Mesenchymal Phenotype’
“Glioblastoma stem cells (GSCs) are potent tumor initiators resistant to radiochemotherapy, and this subpopulation is hypothesized to re-populate the tumor milieu due to selection following conventional therapies. Here, we show that 5-aminolevulinic acid (ALA) treatment— a pro-fluorophore used for fluorescence-guided cancer surgery—leads to elevated levels of fluorophore conversion in patient-derived GSC cultures, and subsequent red light-activation induces apoptosis in both intrinsically temozolomide chemotherapy-sensitive and -resistant GSC phenotypes.” Find the paper and full list of authors in Photochemistry and Photobiology.
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Understanding a tragedy: Miller reviews ‘A Day in the Life of Abed Salama’
Professor of law and international affairs Zinaida Miller reviews Nathan Thrall’s “A Day in the Life of Abed Salama: Anatomy of a Jerusalem Tragedy,” for Just Security. The book analyzes the origins of a tragic school bus accident in 2012 — “the accident could be labeled accidental in only a literal and immediate sense: no one intended, planned, or desired it,” Miller writes. “And yet, the conditions that made a rainy day deadly were far from accidental.” “A Day in the Life of Abed Salama” examines the various structural forces that at play that contributed to such an accident.
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‘Strategic Behavior of Large Language Models and the Role of Game Structure Versus Contextual Framing’
“This paper investigates the strategic behavior of large language models (LLMs) across various game-theoretic settings, scrutinizing the interplay between game structure and contextual framing in decision-making. We focus our analysis on three advanced LLMs—GPT-3.5, GPT-4, and LLaMa-2—and how they navigate both the intrinsic aspects of different games and the nuances of their surrounding contexts. Our results highlight discernible patterns in each model’s strategic approach. GPT-3.5 shows significant sensitivity to context but lags in its capacity for abstract strategic decision making.” Find the paper and full list of authors in Nature: Scientific Reports.
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‘SepsisLab: Early Sepsis Prediction With Uncertainty Quantification and Active Sensing’
“Sepsis is the leading cause of in-hospital mortality in the USA. Early sepsis onset prediction and diagnosis could significantly improve the survival of sepsis patients. Existing predictive models are usually trained on high-quality data with few missing information, while missing values widely exist in real-world clinical scenarios. … The uncertainty of imputation results can be propagated to the sepsis prediction outputs, which have not been studied in existing works on either sepsis prediction or uncertainty quantification.” Find the paper and full list of authors in the proceedings of Knowledge Discovery and Data Mining 2024.
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‘Fidelity of the Kitaev Honeycomb Model Under a Quench’
“We theoretically study the influence of quenched outside disturbances in an intermediately long-time limit. We consider localized imperfections, uniform fields, noise, and couplings to an environment within a unified framework using a prototypical but idealized interacting quantum device—the Kitaev honeycomb model. As a measure of stability we study the Uhlmann fidelity of quantum states after a quench. … Our work provides estimates for the intermediate long-time stability of a quantum device, offering engineering guidelines for quantum devices in quench design and system size.” Find the paper and full list of authors in Physical Review B.
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‘Self-Help Groups and Opioid Use Disorder Treatment: An Investigation Using a Machine Learning-Assisted Robust Causal Inference Framework’
“This study investigates the impact of participation in self-help groups on treatment completion among individuals undergoing medication for opioid use disorder (MOUD) treatment. Given the suboptimal adherence and retention rates for MOUD, this research seeks to examine the association between treatment completion and patient-level factors. Specifically, we evaluated the causal relationship between self-help group participation and treatment completion for patients undergoing MOUD.” Find the paper and full list of authors in the International Journal of Medical Informatics.
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Santillana added to Atlas of Inspiring Hispanic/Latinx Scientists
Mauricio Santillana, a professor of both physics and electrical and computer engineering at Northeastern University, has been added to the Atlas of Inspiring Hispanic/Latinx Scientists, hosted by the Fred Hutch Cancer Center. The atlas is described as “a grassroots effort developed to showcase the expertise, talents, and diversity of Hispanic and Latinx scientific faculty.” Santillana’s research focuses on modeling complex events — like disease outbreaks— through machine learning and network science.
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‘Cosmologically Consistent Analysis of Gravitational Waves From Hidden Sectors’
“Production of gravitational waves in the early Universe is discussed in a cosmologically consistent analysis within a first-order phase transition involving a hidden sector feebly coupled with the visible sector. Each sector resides in its own heat bath leading to a potential dependent on two temperatures and on two fields: one a standard model Higgs field and the other a scalar arising from a hidden sector 𝑈(1) gauge theory. A synchronous evolution of the hidden and visible sector temperatures is carried out from the reheat temperature down to the electroweak scale.” Find the paper and authors list in Physical Review D.
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Discovering the ‘Fundamentals of IoT Communication Technologies’
Rolando Herrero, program director of telecommunication networks and cyber-physical systems at Northeastern University, “presents a comprehensive resource of the Internet of Things and its networking and protocols, intended for classroom use,” according to the publisher’s webpage. The textbook, titled “Fundamentals of IoT Communication Technologies,” is based on a “popular class” that Herrero teaches, and the book includes examples, slides and “a ‘hands-on’ section where the topics discussed as theoretical content are built as stacks in the context of an IoT network emulator.”
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‘Native Capillary Electrophoresis–Mass Spectrometry of Near 1 MDa Non-Covalent GroEL/GroES/Substrate Protein Complexes’
“Protein complexes are essential for proteins’ folding and biological function. Currently, native analysis of large multimeric protein complexes remains challenging. Structural biology techniques are time-consuming and often cannot monitor the proteins’ dynamics in solution. Here, a capillary electrophoresis-mass spectrometry (CE–MS) method is reported to characterize, under near-physiological conditions, the conformational rearrangements of ∽1 MDa GroEL upon complexation with binding partners involved in a protein folding cycle. … This study shows the CE–MS potential to provide information on binding stoichiometry and kinetics for various protein complexes.” Find the paper and full list of authors in Advanced Science.
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‘Prevalence and Correlates of Irritability Among U.S. Adults’
“This study aimed to characterize the prevalence of irritability among U.S. adults, and the extent to which it co-occurs with major depressive and anxious symptoms. A non-probability internet survey of individuals 18 and older in 50 U.S. states and the District of Columbia was conducted between November 2, 2023, and January 8, 2024. … In linear regression models, irritability was greater among respondents who were female, younger, had lower levels of education and lower household income. Greater irritability was associated with likelihood of thoughts of suicide in logistic regression models adjusted for sociodemographic features.” Find the paper and authors list…
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‘Sophisticated Natural Products as Antibiotics’
“In this Review, we explore natural product antibiotics that do more than simply inhibit an active site of an essential enzyme. We review these compounds to provide inspiration for the design of much-needed new antibacterial agents. … Many of the compounds exhibit more than one notable feature, such as resistance evasion and target corruption. Understanding the surprising complexity of the best antimicrobial compounds provides a roadmap for developing novel compounds to address the antimicrobial resistance crisis by mining for new natural products and inspiring us to design similarly sophisticated antibiotics.” Find the paper and full list of authors in Nature.
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‘Changes in Cerebral Vascular Reactivity Following Mild Repetitive Head Injury in Awake Rats: Modeling the Human Experience’
“The changes in brain function in response to mild head injury are usually subtle and go undetected. Physiological biomarkers would aid in the early diagnosis of mild head injury. In this study we used hypercapnia to follow changes in cerebral vascular reactivity after repetitive mild head injury. … The changes in vascular reactivity were not uniform across the brain. The prefrontal cortex, somatosensory cortex and basal ganglia showed the hypothesized decrease in vascular reactivity while the cerebellum, thalamus, brainstem, and olfactory system showed an increase in BOLD signal to hypercapnia.”Find the paper and list of authors in Experimental Brain Research.
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‘Strategies to Optimize the Deployment of Roadway Maintenance Machines for Overnight Maintenance in Urban Rail Systems’
“This research investigates the effectiveness of several strategies to deploy roadway maintenance machines (RMMs) in preparation for overnight maintenance in rapid transit systems. Owing to the short windows of time available for maintenance activities in the overnight period (i.e., when revenue service is suspended), efficient deployment of RMMs is an important aspect of ensuring adequate productive time for crews at work locations. Four deployment strategies are investigated.” Find the paper and full list of authors in Transportation Research Record.
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Caracoglia to model new wind turbine designs
Luca Caracoglia, professor of civil and environmental engineering, has received NSF funding for a project titled, “Modeling the Influence of Turbulence on Flow-Induced Instabilities of Large Flexible Structures With Innovative Applications in Wind Turbine Blades.” Caracoglia will be designing stochastic models to “promote safe design of next-generation offshore wind turbine structures by enabling slender and lighter blade designs,” the abstract states.
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Production of ‘How God Works’ will continue thanks to Templeton
Professor of psychology David DeSteno’s award-winning podcast, “How God Works: The Science Behind Spirituality,” has received funding for another year of production from the Templeton Foundation.
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When is it all right to ReTIRE those old tires? Zhenyu Tian wants to find out
“In this project,” titled “ReTIRE: Research on Transformations, Implications, and Risks of End-of-life tires,” writes Zhenyu Tian, assistant professor of chemistry and chemical biology, “the investigators study the environmental transformation, fate, and impact of end-of-life tires with advanced analytical methods. The results will help us understand the risk of current tire reuse practices (e.g., crumb rubber in artificial turf) and inform better waste management and product design.”
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‘Mechanomemory of Nucleoplasm and RNA Polymerase II After Chromatin Stretching by a Microinjected Magnetic Nanoparticle Force’
With this paper, professor of bioengineering Ning Wang, working with Ph.D. students Fazlur Rashid and Sadia Kabbo, demonstrates a process of “mechanomemory” in the chromatin of cells. “The mechanics of chromatin and nucleoplasm regulate gene transcription and nuclear function,” they write. “However, how the chromatin and nucleoplasm sense and respond to forces remains elusive.” Their results imply that “the viscoelastic behavior of the chromatin … provide[s] concrete evidence that the chromatin does not behave like a pure liquid, as concluded in one study, nor like a solid, as concluded in another study.” Find the full paper in Cell Reports.
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‘Strategic Behavior of Large Language Models and the Role of Game Structure Versus Contextual Framing’
“This paper investigates the strategic behavior of large language models (LLMs) across various game-theoretic settings, scrutinizing the interplay between game structure and contextual framing in decision-making. We focus our analysis on three advanced LLMs—GPT-3.5, GPT-4, and LLaMa-2—and how they navigate both the intrinsic aspects of different games and the nuances of their surrounding contexts. Our results highlight discernible patterns in each model’s strategic approach.” Find the paper and full list of authors in Scientific Reports.
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‘Lipid Nanoparticles Target Haematopoietic Stem Cells’
In this review, University Distinguished Professor of pharmaceutical sciences and chemical engineering Mansoor Amiji, with co-author Dimitrios Bitounis, discuss “a novel class of non-viral lipid nanoparticle (LNP)-based formulations for the in vivo delivery of genetic therapies to HSC [haematopoietic stem cells] in the bone marrow with the potential to treat blood disorders,” which have the potential to overcome clinical risks that “require removal of the patients own HSC, their curative modification, and transplantation back to the patient.”
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How the placebo effect masks cognitive training gains
In this book chapter, titled “Expectations and Placebo Effects in the Context of Cognitive Training,” professors of psychology Susanne Jaeggi and Aaron Seitz, with co-authors Jocelyn Parong and C. Shawn Green, discuss the difficulties of quantifying the improvements brought on by cognitive training, as “the curse of specificity” means one form of cognitive training will often not create improvement in other areas. “The very nature of cognitive training interventions,” they write, “makes placebo effects a possible concern.”
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Northeastern partners with National Science Foundation to launch regional research security center
Backed by a five-year $4.9 million investment from the NSF, the center will be an information clearinghouse for the research community.
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How Nackey Scripps Loeb became the Republican Party’s ‘Political Godmother’
Associate professor Meg Heckman’s book, “Political Godmother: Nackey Scripps Loeb and the Newspaper That Shook the Republican Party” tells the story of “Newspaper publisher and GOP kingmaker Nackey Scripps Loeb,” according to the publisher’s webpage. Heckman’s examination “reveals Loeb as a force of nature, more than willing to wield her tremendous clout and able to convince the likes of Pat Buchanan to challenge a sitting president.”
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Teaching ophthalmology virtually: Two solutions
Tony Succar, lecturer in the College of Professional Studies, has co-authored a book chapter titled, “Digital Teaching and Learning: The Future of Ophthalmology Education,” which “highlights two digital teaching programs developed by” Succar’s working group, “implemented to act as a countermeasure to the restrictions placed in response to the pandemic,” the authors write. These programs “have proven that face-to-face learning is not required for all aspects of the ophthalmology medical student teaching,” and will continue to be employed post-pandemic. Find the chapter and full list of authors at “Digital Teaching, Learning and Assessment: The Way Forward,” or on Science Direct.