“Tissues and other cell populations are highly heterogeneous. … The ability to assess this heterogeneity is crucial in understanding numerous biological phenomena, including various pathologies. Traditional analyses apply bulk-cell sampling, which masks the potentially subtle differences between cells. … These limitations due to cell heterogeneity inspired significant efforts and interest toward the analysis of smaller sample sizes, down to the level of individual cells. In this review, we focus on the application of [capillary electrophoresis and mass spectrometry] in the proteomic and metabolomic profiling of single cells.”

Find the paper and the full list of authors in Trends in Analytical Chemistry.