Title

Topic

  • ‘Evaluating Protein Cross-Linking as a Therapeutic Strategy to Stabilize SOD1 Variants in a Mouse Model of Familial ALS’

    , , , , ,

    “Mutations in the gene encoding Cu-Zn superoxide dismutase 1 (SOD1) cause a subset of familial amyotrophic lateral sclerosis (fALS) cases. A shared effect of these mutations is that SOD1, which is normally a stable dimer, dissociates into toxic monomers that seed toxic aggregates. Considerable research effort has been devoted to developing compounds that stabilize the dimer of fALS SOD1 variants, but unfortunately, this has not yet resulted in a treatment. We hypothesized that cyclic thiosulfinate cross-linkers, which selectively target a rare, 2 cysteine-containing motif, can stabilize fALS-causing SOD1 variants in vivo.” Find the paper and list of authors at PLOS Biology.

    Learn more

  • ‘Exploring the Indian Political YouTube Landscape: A Multimodal Multi-Task Approach’

    ,

    “Social media profoundly influences all facets of our lives, including politics. Political parties, politicians, and media outlets have strategically cultivated their social media presence to engage with the public. However, with the advent of freely available Internet services in India, there has been a rising proliferation in the community of independent content creators on YouTube, with many getting millions of views per video. In this study, we present a novel multimodal dataset of videos, taken from 20 independent and influential content creators. … By introducing this novel dataset, we aim to stimulate further investigation within the domains of opinion dissemination…

    Learn more

  • ‘Deploying and Evaluating LLMs to Program Service Mobile Robots’

    “Recent advancements in large language models (LLMs) have spurred interest in using them for generating robot programs from natural language, with promising initial results. We investigate the use of LLMs to generate programs for service mobile robots leveraging mobility, perception, and human interaction skills, and where accurate sequencing and ordering of actions is crucial for success. We contribute CodeBotler, an open-source robot-agnostic tool to program service mobile robots from natural language, and RoboEval, a benchmark for evaluating LLMs’ capabilities of generating programs to complete service robot tasks.” Find the paper and full list of authors at ArXiv.

    Learn more

    , ,
  • Ferrins receives NIH AViDD Center Development Grant

    “There are two goals in this project, firstly, to continue to develop our advanced hit compound … to identify a lead suitable for in vivo proof of concept studies. Secondly, to develop novel methods to study the structural dynamics of both covalent inhibitors and PLpro active site structures enabling the development of more potent covalent inhibitors.”

    Learn more

    ,
  • ‘Adaptive thresholding increases sensitivity to detect … rate of skin conductance responses to psychologically arousing stimuli’

    “Psychophysiologists recording electrodermal activity (EDA) often derive measures of slow, tonic activity—skin conductance level (SCL)—and faster, more punctate changes—skin conductance responses (SCRs). … We developed a fixed plus adaptive (FA) thresholding method that adjusts identification of SCRs based on an individual’s SC at the onset of the SCR to increase statistical power and include data from more participants. We assess the utility of applying FA thresholding across two independent samples and explore age and race-related associations with EDA outcomes.” Find the paper and full list of authors at the International Journal of Psychophysiology.

    Learn more

  • ‘Fossil Fuel Interests in Puerto Rico: Perceptions of Incumbent Power and Discourses of Delay’

    , ,

    “This study explores perceptions of fossil fuel interests and the role narratives of fossil fuel obstruction play in slowing down the renewable energy transition in Puerto Rico. We analyzed interviews conducted with 56 ‘energy actors’ engaged in Puerto Rico’s energy system. … Our interviews revealed that a wide range of energy actors perceived obstruction by fossil fuel interests as shaping Puerto Rico’s energy transition and used discourses of delay to describe Puerto Rico’s energy transition, but also employed narratives that countered this obstruction and resisted fossil fuel interests.” Find the paper and list of authors in Energy Research and Social…

    Learn more

    , ,
  • ‘Interpretation Issues With “Genomic Vulnerability” Arise From Conceptual Issues in Local Adaptation and Maladaptation’

    “As climate change causes the environment to shift away from the local optimum that populations have adapted to, fitness declines are predicted to occur. Recently, methods known as genomic offsets (GOs) have become a popular tool to predict population responses to climate change from landscape genomic data. Populations with a high GO have been interpreted to have a high ‘genomic vulnerability’ to climate change. … This study uses hypothetical and empirical data to explore situations in which different types of fitness offsets may or may not be correlated with each other or with a GO.”

    Learn more

    ,
  • ‘A Network-Based Normalized Impact Measure Reveals Successful Periods of Scientific Discovery Across Disciplines’

    “The impact of a scientific publication is often measured by the number of citations it receives from the scientific community. However, citation count is susceptible to well-documented variations in citation practices across time and discipline, limiting our ability to compare different scientific achievements. Previous efforts to account for citation variations often rely on a priori discipline labels of papers, assuming that all papers in a discipline are identical in their subject matter. Here, we propose a network-based methodology to quantify the impact of an article by comparing it with locally comparable research.” Find the paper and authors list at PNAS.

    Learn more

  • Meni Wanunu, developer of sensitive biological sensors, receives Northeastern University NAI Innovator of the Year Award

    Professor of physics and chemistry and chemical biology Meni Wanunu develops “nanopores,” sensors composed of molecule-sized holes that stretch individual molecules for scientific observation. At this year’s annual gathering of the Northeastern chapter of the National Academy of Inventors, Wanunu received the Innovator of the Year Award.

    Learn more

    , ,
  • Dean Hazel Sive edits volume detailing African frog research and best practices that informed her ‘life’s work’

    Dean of the College of Science and professor of biology at Northeastern University Hazel Sive has edited “Xenopus: A Laboratory Manual,” a new textbook that presents “a comprehensive collection of experimental procedures for research using Xenopus.”

    Learn more

  • How family doctors can save ‘Primary Care on the Brink’: Hoff argues for the return of the generalist

    In “Searching for the Family Doctor: Primary Care on the Brink,” Timothy Hoff, professor of management, health care systems and public policy, argues that “The family doctor,” according to the publisher’s webpage, “was conceived of as a powered-up version of the ‘country doctor’ idea. At a time when doctor-patient relationships are evaporating in the face of highly transactional, fast-food-style medical practice, this ideal seems both nostalgic and revolutionary.” Hoff explores “how to save primary care by giving family doctors a fighting chance to become the generalists we need in our lives.”

    Learn more

    ,
  • ‘Inhalable Bottlebrush Polymer Bioconjugates as Vectors for Efficient Pulmonary Delivery of Oligonucleotides’

    “Antisense oligonucleotides hold therapeutic promise for various lung disorders, but their efficacy is limited by suboptimal delivery. To address this challenge, we explored the use of inhaled bottlebrush polymer–DNA conjugates, named pacDNA, as a delivery strategy. Inhaled pacDNA exhibits superior mucus penetration, achieving a uniform and sustained lung distribution in mice.” Find the paper and full list of authors at ACS Nano.

    Learn more

    ,
  • ‘Unveiling the Degradation of Pt/NbOx/C Catalysts in PEMFCs via In Situ X-ray Absorption Spectroscopy’

    ,

    “Among the class of the catalyst that is composed of metal nanoparticles supported on metal oxides (MMO), the Pt/NbOx/C system has shown promising oxygen reduction reaction (ORR) activities as a cathode of proton exchange membrane fuel cells (PEMFCs). Herein, we have studied a series of Pt/NbOx/C catalysts prepared via physical vapor deposition and unraveled the nature of the metal and metal oxide interaction (MMOI) by characterizing this system under reactive conditions. … We demonstrate that Pt preferably interacts with O but not Nb in the Pt/NbOx/C system.” Find the paper and full list of authors at Journal of The Electrochemical Society.

    Learn more

    , ,
  • New book collecting cutting-edge, evidence-based research on crime and justice policy aims to ‘chip away at the resistance to change’

    , , ,

    Professor of criminology and criminal justice Brandon Welsh has co-edited “The Oxford Handbook of Evidence-Based Crime and Justice Policy,” which contains 32 chapters of research around evidence-based policy in practice from over 50 “scholars and practitioners.”

    Learn more

    ,
  • ‘The Expressive Function of Public Policy: Renewable Energy Mandates Signal Social Norms’

    “Addressing collective action problems requires individuals to engage in coordinated and cooperative behaviours. Existing research suggests that individuals’ propensity to work together depends in part on their belief that others support the cause in question. People form their expectations about prevalent beliefs and behaviours from many sources. To date, most of the literature has focussed on how social norm perceptions are inferred from peers or summary statistics. We explore an understudied source of norm information: the passage of policies by democratically elected institutions.” Find the paper and full list of authors in Philosophical Transactions of the Royal Society B.

    Learn more

    ,
  • ‘Local Adaptation in Trait-Mediated Trophic Cascades’

    “Predator-induced changes in prey foraging can influence community dynamics by increasing the abundance of basal resources via a trait-mediated trophic cascade. The strength of these cascades may be altered by eco-evolutionary relationships between predators and prey, but the role of basal resources has received limited attention. We hypothesized that trait-mediated trophic cascade strength may be shaped by selection from trophic levels above and below prey. … We suggest that adaptation to basal resource availability may shape geographical variation in the strength of trait-mediated trophic cascades.” Find the paper and full list of authors at Proceedings of the Royal Society B.

    Learn more

    ,
  • ‘Does More Advice Help? The Effects of Second Opinions in AI-Assisted Decision Making’

    “AI assistance in decision-making has become popular, yet people’s inappropriate reliance on AI often leads to unsatisfactory human-AI collaboration performance. In this paper, through three pre-registered, randomized human subject experiments, we explore whether and how the provision of {second opinions} may affect decision-makers’ behavior and performance in AI-assisted decision-making. We find that if both the AI model’s decision recommendation and a second opinion are always presented together, decision-makers reduce their over-reliance on AI while increase their under-reliance on AI.” Find the paper and full list of authors at ArXiv.

    Learn more

    ,
  • Dy elected as Fellow of Association for the Advancement of Artificial Intelligence

    Professor Jennifer Dy, in the Khoury College of Computer Sciences and in the department of electrical and computer engineering, was elected as a Fellow of the Association for the Advancement of Artificial Intelligence (AAAI) “For significant contributions to unsupervised and interpretable machine learning, advancing AI to address health care challenges and service to the AI community,” the organization wrote in its announcement.

    Learn more

    , ,
  • Cassella added to Fulbright Specialist Roster

    “Electrical and computer engineering associate professor Cristian Cassella was recommended by a panel of the U.S. Department of State’s Bureau of Educational and Cultural Affairs and World Learning to join the prestigious Fulbright Specialist Roster for a tenure of three years. The program, which is part of the larger Fulbright Program, pairs highly qualified U.S. academics and professionals with host institutions in over 150 countries to share their expertise, strengthen institutional linkages, hone their skills, gain international experience and learn about other cultures while building capacity at their overseas host institutions.”

    Learn more

  • ‘Native Capillary Electrophoresis–Mass Spectrometry of Near 1 MDa Non-Covalent GroEL/GroES/Substrate Protein Complexes’

    , ,

    “Protein complexes are essential for proteins’ folding and biological function. Currently, native analysis of large multimeric protein complexes remains challenging. Structural biology techniques are time-consuming and often cannot monitor the proteins’ dynamics in solution. Here, a capillary electrophoresis-mass spectrometry (CE–MS) method is reported to characterize, under near-physiological conditions, the conformational rearrangements of ∽1 MDa GroEL upon complexation with binding partners involved in a protein folding cycle.” Find the paper and full list of authors at Advanced Science.

    Learn more

    ,
  • ‘Emotion Regulation Convoys: Individual and Age Differences in the Hierarchical Configuration of Emotion Regulation Behaviors in Everyday Life’

    “A key limitation of studying emotion regulation behavior is that there is currently no way to describe individual differences in use across a range of tactics, which could lead to investigations of intraindividual changes over time or interindividual differences as a function of personality, age, culture, or psychopathology diagnosis. We, therefore, introduce emotion regulation convoys. This research tool provides a snapshot of the hierarchy of emotion regulation tactics an individual favors across everyday life situations and how effective they are at regulating moods.” Find the paper and full list of authors at Research Gate.

    Learn more

  • AI-driven testing for cellular networks

    , , , ,

    “Electrical and computer engineering assistant research professor Michele Polese is leading a $2 million project awarded by the Wireless Innovation Fund for ‘AutoRAN: Automated End-to-End Continuous Testing for Open and Disaggregated Cellular Systems.’ … The project will explore the use of AI and large language models to streamline the process of testing the performance of multi-vendor Open RAN networks. Electrical and computer engineering assistant research professor Salvatore D’Oro, associate research scientist Leonardo Bonati, principal research scientist Pedram Johari and professor Tommaso Melodia will also be collaborating on this project.”

    Learn more

    ,
  • ‘Linear Extension and Calcification Rates in a Cold-Water, Crustose Coralline Alga are Modulated by Temperature, Light and Salinity’

    “Long-lived crustose coralline algae are important ecosystem engineers and environmental archives in regions where observations of climate variability are sparse. … Here, we present the results of the first, to-our-knowledge, controlled laboratory experiment isolating the effects of light, temperature, and salinity on calcification rates of C. compactum. Algal calcification rates were modulated by a combination of light exposure, salinity, and temperature, where temperature and salinity were positively correlated, and light level was negatively correlated with calcification rate.” Find the paper and full list of authors in Limnology and Oceanography.

    Learn more

  • Karma receives NASA grant to study alloy solidification in space

    The COMPASS project — “Computational Modeling of Columnar‐Equiaxed Alloy Solidification Micro‐Structures” — “uses computational modeling and space experiments conducted aboard the International Space Station to develop a fundamental understanding of the alloy solidification process used to make a wide range of technological materials.”

    Learn more

    ,
  • Jaeggi and Seitz receive DoD grant to develop attention-measuring tools in high performers

    ,

    “In this collaborative project that involves groups from Washington University (St. Louis), Brown University, University of California, Irvine, as well as several groups in Australia, we develop tools / apps to assess attention control in high-performing adults (e.g., pilots or air-traffic controllers) using computational modeling as well as behavioral and neuroimaging methods. Furthermore, we build evidence-based interventions to maximize and improve attention control functions in various [stressful] environments … The outcome of our project will provide a better understanding of the human attention system and the interventions will enable individuals to maintain high levels of focus and concentration even in…

    Learn more

  • ‘Enabling Rotation Over Electrophoretic Motion in Janus Particles Under Applied Electric Field’

    “Janus particles (JPs) comprising metal and dielectric halves are capable of propulsion perpendicular to an applied electric field, with promising applications in targeted drug delivery and microrobotics. Yet, not all JP geometries behave the same when activated. We explore hemispherical, snowman and matchstick-like particle dynamics and evaluate threshold values for which electric torque can overcome induced charge electrophoresis. We define conditions where JPs are more likely to undergo rotation in place rather than linear motion, highlighting design features which should be considered when using these particles as materials.” Find the paper and full list of authors at Applied Physics Letters.

    Learn more

  • ‘The Effects of Lithium Chloride Exposure on the Reproduction of Caenorhabditis elegans’

    “Caenorhabditis elegans (C. elegans) are model organisms that share similar anatomical structures to humans. By exploring the effects of lithium chloride (LiCl) on C. elegans, we can collect crucial data regarding the compound’s impact on patients taking psychiatric medications containing LiCl. Here we performed an egg retention assay on nematode populations to explore how LiCl can influence reproduction. We found a statistically significant difference in eggs retained between control and experimental groups, suggesting that LiCl has negative effects on reproductive health.” Find the paper and full list of authors at MicroPublication Biology.

    Learn more

    ,
  • Ionescu receives NSF CAREER award to study ‘molecular mechanisms of skeletal growth’

    “This Faculty Early Career Development (CAREER) award will focus on elucidating the molecular mechanisms of skeletal growth. … Estrogen plays a vital role in growth plate closure for both sexes [of mammals] by converting androgens to estrogens through aromatase in growth plate cartilage. Deficiency or resistance to estrogen leads to growth plate fusion failure and ongoing height increase in adulthood. However, the exact mechanism by which estrogen regulates growth plate closure is still unknown. Understanding this mechanism may clarify species-specific skeletal differences or variations between bones from different anatomical locations.”

    Learn more

  • Two members of the Northeastern community elected ACM Fellows for contributions to artificial intelligence and advances in computer science

    Professor of the practice at Northeastern University Kenneth Church and Northeastern graduate Natasha Noy have been elected 2023 ACM Fellows. Both Church and Noy have advanced research in artificial intelligence, and both have worked on tools to support other researchers’ efforts.

    Learn more

  • For teaching computers to see, Northeastern professor receives eminent achievement award

    A leading researcher in the field of computer vision — which uses artificial intelligence to process images received from cameras that “mimic human eyes” — Yun Raymond Fu, distinguished professor in the department of electrical and computer engineering, has received the 2024 Edward J. McCluskey Technical Achievement Award for making “impactful contributions” over a nearly 20-year career.

    Learn more

    , ,