Title
Topic
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‘Dose-dependent effects of GAT107…: A BOLD phMRI and connectivity study on awake rats’
“Alpha 7 nicotinic acetylcholine receptor (α7nAChR) agonists have been developed to treat schizophrenia but failed in clinical trials due to rapid desensitization. GAT107, a type 2 allosteric agonist-positive allosteric modulator (ago-PAM) to the α7 nAChR was designed to activate the α7 nAChR while reducing desensitization. We hypothesized GAT107 would alter brain neural circuitry associated with cognition, emotion, and sensory perception.Methods: The present study used pharmacological magnetic resonance imaging (phMRI) to evaluate the dose-dependent effect of GAT107 on brain activity in awake male rats.” Read the paper and see the full list of authors at Frontiers in Neuroscience.
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Biodegradable nanogenerators lead to less electronic waste
In “Aligned PLLA electrospun fibres based biodegradable triboelectric nanogenerator,” the authors present a new construction method for potential components in energy harvesters. These energy harvesters—like solar cells—”are not always developed using sustainable materials.” Creating components that are biodegradable could make these devices more environmentally friendly. “The presented approach,” the authors argue, “can provide attractive green energy harvesting machine to power portable devices at a large scale—without having to worry about the end-of-life electronic waste management.” Find the full list of authors in Nano Energy.
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‘MSNetViews: Geographically Distributed Management of Enterprise Network Security Policy’
“Commercially-available software defined networking (SDN) technologies will play an important role in protecting the on-premises resources that remain as enterprises transition to zero trust architectures. However, existing solutions assume the entire network resides in a single geographic location, requiring organizations with multiple sites to manually ensure consistency of security policy across all sites. In this paper, we present MSNetViews, which extends a single, globally-defined and managed, enterprise network security policy to many geographically distributed sites.” Read the paper and see the full list of authors at the Association for Computing Machinery.
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Using ‘recycled plastic as a building material’ on exhibit at 2023 Venice Biennale
Assistant professor of architecture Ang Li exhibited work at the U.S. Pavilion of the 2023 Venice Biennale. Li’s work conducts “investigations into the use of recycled plastic as a building material and structural system.” Read more about Li’s work and the other invited artists at Archinect.
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‘Why We Should Care About Moral Foundations When Preparing for the Next Pandemic: Insights From Canada, the UK and the US’
“Health behaviors that do not effectively prevent disease can negatively impact psychological wellbeing and potentially drain motivations to engage in more effective behavior, potentially creating higher health risk. Despite this, studies linking “moral foundations” (i.e., concerns about harm, fairness, purity, authority, ingroup, and/or liberty) to health behaviors have generally been limited to a narrow range of behaviors, specifically effective ones. We therefore explored the degree to which moral foundations predicted a wider range of not only effective but ineffective (overreactive) preventative behaviors during the COVID-19 pandemic.” Read the paper and see the full list of authors at PLOS ONE.
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‘Resting-State MRI Functional Connectivity as a Neural Correlate of Multidomain Lifestyle Adherence’
“Prior research has demonstrated the importance of a healthy lifestyle to protect brain health and diminish dementia risk in later life. While a multidomain lifestyle provides an ecological perspective to voluntary engagement, its association with brain health is still under-investigated. … Self-reported exercise engagement, cognitive activity engagement, healthy diet adherence, and social activity engagement were included to examine potential phenotypes of an individual’s lifestyle adherence. … The features that show consistently high importance to the classification model were functional connectivity mainly between nodes located in different prior-defined functional networks.” Find the paper and the full list of authors in Scientific…
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Closas receives Best Paper in Track Award for work on signal jamming
“Associate Professor Pau Closas received the Best Paper in Track Award at the 2023 IEEE/ION Position, Location and Navigation Symposium (PLANS) for the work ‘Jammer Classification with Federated Learning,’ with electrical engineering students Peng Wu and Helena Calatrava, and Associate Research Scientist Tales Imbiriba.”
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Odom explains why companies need ‘a clear purpose’ to be effective
“We’re in the middle of a pivotal moment where purpose, value and meaning are essential for business,” Curtis Odom, associate teaching professor of management and organizational development, writes. It’s vital that businesses identify “a clear purpose [that] can help a company differentiate itself from competitors, inspire and motivate employees, and build or maintain a strong brand identity.” Odom continues by describing how leaders can re-evaluate, and re-instill, purpose in their company and among their employees.
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‘How Informal Entrepreneurship Impacts Innovation in Emerging Economies’
“New ventures in emerging markets, initially created informally, suffer from costs that persist and constrain a firm’s ability to innovate even after they formalize their status. … Informally created new ventures are more likely to develop imitative rather than innovative new products. However, being acquired by other firms and improvements in the national innovation system can weaken the persistence of these informality costs. … The concept of internal imprinting … captures how the internal characteristics of a company result in the establishment of practices that persist over time.” Find the paper and the list of authors at the Insights @…
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‘Attention to Emotional Stimuli Across Adulthood and Older Age: A Novel Application of Eye-Tracking Within the Home’
“Previous research has used stationary eye-tracking in the lab to examine age differences in attentional deployment, showing that older adults display gaze patterns toward positive stimuli. … However, the lab environment may lead to different emotion regulation behavior among older adults compared to what they do in their everyday life. We, therefore, present the first use of stationary eye-tracking within participants’ homes to examine gaze patterns toward video clips of varying valence and to study age differences in emotional attention … in a more naturalistic environment.” Read the paper and see the full list of authors at APA PsycNet.
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‘How Digitally Enhanced Autonomous Teams Make Chinese Companies More Agile’
“Chinese companies are reinventing management through an approach called “digitally enhanced directed autonomy” (DEDA). DEDA uses digital platforms to give frontline employees direct access to corporate resources and capabilities, allowing them to organize themselves around business opportunities without managerial intervention. Autonomy is directed where it is needed and tracked. By giving teams the freedom to design, produce, and sell their products, companies can foster innovation, increase employee engagement, and improve customer satisfaction.” Read the paper and see the full list of authors at the Insights @ Center for Emerging Markets.
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‘Location Effects of the UN Environment Program (UNEP) in Nairobi Kenya: Challenges and Opportunities’
“In 1972, Nairobi, Kenya became the first developing country to host the headquarters of a UN organization, the UN Environment Programme (UNEP). UNEP’s presence in Nairobi has increased Kenya’s global governance stature. However, it has not fulfilled the promise of promoting greater input from developing countries. The location has posed challenges to UNEP, including security concerns, recruitment and retention of staff, communication and infrastructure difficulties, and the need for resources.” Read the paper and see the full list of authors at the Insights @ Center for Emerging Markets.
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‘Optimal Cancer Evasion in a Dynamic Immune Microenvironment Generates Diverse Post-Escape Tumor Antigenicity Profiles’
“The failure of cancer treatments, including immunotherapy, continues to be a major obstacle in preventing durable remission. This failure often results from tumor evolution, both genotypic and phenotypic, away from sensitive cell states. Here, we propose a mathematical framework for studying the dynamics of adaptive immune evasion that tracks the number of tumor-associated antigens available for immune targeting.” Read the paper and see the full list of authors at ELife Sciences.
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‘Conceptualizing Human–Nature Relationships: Implications of Human Exceptionalist Thinking’
“Human exceptionalism (HE) … involv[es] the belief that humans and human societies exist independently of the ecosystems in which they are embedded, promoting a sharp ontological boundary between humans and the rest of the natural world. In this paper, we introduce HE in more depth, exploring the impact of HE on perceptions of the human–nature relationship, the role of culture in HE, and speculating on the origins of HE. We consider potential implications for environmental decision-making, conservation and environmental science, and promoting proenvironmental behavior. ” Read the paper and see the full list of authors at Topics in Cognitive Science.
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‘Cell Invasion During Competitive Growth of Polycrystalline Solidification Patterns’
“Spatially extended cellular and dendritic array structures forming during solidification processes … are generally polycrystalline. Both the array structure within each grain and the larger scale grain structure determine the performance of many structural alloys. How those two structures coevolve during solidification remains poorly understood. By in situ observations of microgravity alloy solidification experiments onboard the International Space Station, we have discovered that individual cells from one grain can unexpectedly invade a nearby grain of different misorientation, either as a solitary cell or as rows of cells.” Read the paper and see the full list of authors in Nature Communications.
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‘Body Mechanics, Optimality and Sensory Feedback in the Human Control of Complex Objects’
“Humans are adept at a wide variety of motor skills, including the handling of complex objects and using tools. Advances to understand the control of voluntary goal-directed movements have focused on simple behaviors such as reaching, uncoupled to any additional object dynamics. … This study examined a task with internal dynamics, inspired by the daily skill of transporting a cup of coffee, with additional expected or unexpected perturbations to probe the structure of the controller.” Read the paper and see the full list of authors in Neural Computation.
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‘Changes in Water Flow Alter Community Dynamics in Oyster Reefs’
Professor of marine and environmental sciences Jonathan Grabowski, with professor Sean Powers from the University of South Alabama, has published a new paper in Ecosphere. “Water flow can influence individual fitness and local population dynamics, but less is known about the collective response of natural communities to alteration in water flow. … To examine how changes in water flow affected initial larval settlement patterns of epifaunal and infaunal animals, colonization of larger individuals, and prey survival, we manipulated water flow (−50% or +47%) in situ using large wooden channels over small experimental oyster reefs.”
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‘Why Do We Need to Learn about Citational Practices?’
“How do you decide which papers to cite, how many, and from which particular sources? We reflect and discuss the implications of these critical questions based on our experiences in the panel and workshops on the topic of citational justice that took place at CSCW, CLIHC, and India HCI in 2021.” Read the paper and see the full list of authors in XRDS: Crossroads.
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‘Automated Active Space Selection With Dipole Moments’
“Selecting a suitable active space for multireference calculations is nontrivial, and the selection of an unsuitable active space can sometimes lead to results that are not physically meaningful. … In this work, we have developed and evaluated two protocols for automated selection of the active space for multireference calculations based on a simple physical observable, the dipole moment, for molecules with nonzero ground-state dipole moments.” Find the paper and the full list of authors at the Journal of Chemical Theory and Computation.
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Fayyad answers ‘Why Most Machine Learning Applications Fail To Deploy’
Despite the recent excitement around artificial intelligence endeavors, especially chatbots like ChatGPT, professor of practice and the executive director of the Institute for Experiential AI at the Roux Institute Usama Fayyad points out how, in enterprise environments, machine learning projects often fail to get off the ground. In evaluating how businesses can more successfully deploy those projects, Fayyad points to several options, including estimating the return on investment, building trust, and more.
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Carrier receives honorable mention for advancing macular degeneration research
“Chemical engineering professor Rebecca Carrier received an honorable mention during the National Eye Institute 3-D Retina Organoid Challenge. Carrier’s team created an organoid-microvessel co-culture system that proposes to add vasculature embedded in a biomimetic hydrogel to organoids to increase oxygen and nutrient flow and mimic the chemical and physical cues present in developing eye tissue. The system also includes retinal pigmented epithelium and can be used to model and study age-related macular degeneration.” Read more about the associated research at the National Institutes of Health.
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Hashmi receives NSF CAREER Award for work illuminating blood clots
“Chemical engineering assistant professor Sara Hashmi was awarded a $550,000 NSF CAREER award for ‘In situ Polymer Gelation in Confined Flows’ to examine how polymer gels flow through tight spaces to better predict clogging behavior such as blood flow through a vessel.”
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‘Protected or Porous: A Comparative Analysis of Threat Detection Capability of IoT Safeguards’
“Consumer Internet of Things (IoT) devices are increasingly common, from smart speakers to security cameras, in homes. Along with their benefits come potential privacy and security threats. To limit these threats a number of commercial services have become available (IoT safeguards). The safeguards claim to provide protection against IoT privacy risks and security threats. However, the effectiveness and the associated privacy risks of these safeguards remains a key open question. In this paper, we investigate the threat detection capabilities of IoT safeguards for the first time.” Read the paper and see the full list of authors in ArXiv.
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‘High Purity Hydrogen Separation With HT-PBI Based Electrochemical Pump Operation at 120 °C’
“Electrochemical Hydrogen Pumps (EHP) provide a unique highly efficient means of separating and compressing hydrogen with continuous steady-state operation. In this paper, we demonstrate the performance of a commercially available, polybenzimidazole (PBI) membrane based platform as a benchmark for ultra-high efficiency performance.” Read the paper and see the full list of authors in the Journal of The Electrochemical Society.