State officials and industry leaders today will hold the first meeting of the Advanced Manufacturing Collaborative to draw attention to a sector whose work force is aging and projected to have 100,000 job openings over the next decade.

While some analysts have predicted the decline of industry as a major economic player, manufacturing is Massachusetts’ fifth-largest private sector, accounting for some 7,500 companies and 250,000 jobs, said Northeastern University Professor Barry Bluestone, who serves on the collaborative’s board.