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PNAS
Disorder guides protein function
Cellular function requires biomolecules to undergo dynamic transitions that include folding, conformational rearrangements, and large-scale assembly. The result is a highly interdependent network of processes that is maintained by a balance of thermodynamic and kinetic factors. In molecular machines, each constituent biopolymer (i.e., a chain of residues) first folds to a low energy configuration/ensemble. These ordered polymers can then assemble into sophisticated architectures, […]
The New Science Behind Your Spending Addiction
Like many colleges, Washington University in St. Louis offers children of its faculty free tuition. So Leonard Green, a professor of psychology there, did all he could to persuade his daughter to choose the school. He extolled its academic offerings, praised its social atmosphere, talked up its extracurricular activities—and promised that if Hannah chose Washington […]