Undertaking protein analysis using limited or single-cell samples “requires specialized methods that prioritize high sensitivity and minimize sample loss.” Professor Alexander Ivanov, PhD. candidates Kendall R. Johnson and Yunfan Gao, and postdoctoral researcher Michal Greguš, present new methods “in single-cell proteome-level profiling,” which offer high sensitivity rates and the potential for deep protein analysis based on individual cells.

Read their research paper, “On-capillary Cell Lysis Enables Top-down Proteomic Analysis of Single Mammalian Cells by CE-MS/MS,” at ACS Publications.